The Journal of Phytopharmacology 2024; 13(1):1-3 ; DOI:10.31254/phyto.2024.13101
Antiproliferative effect of methanolic extract of Mallotus philippensis in MCF-7 cell lines
Sujith Samraj1 , Nisaath Begum2 , Alfin Mariya3 , Arya Mohan4 , Nisha AR5
1. Assistant Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Kerala 680651, India
2. Ph D scholar, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, India
3. MSc Scholar, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur 680651, India
4. Teaching Assistant, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur 680651, India
5. Associate Professor and Head, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur 680651, India
*Author to whom correspondence should be addressed.
Received: 1st October, 2023 / Accepted: 15th December, 2023 / Published : 28th February, 2024
Phytochemicals and their derivatives are promising options for improving cancer treatment efficiency while minimising side effects. Methanolic extract of flowers of Mallotus philippensis were assessed for their cytotoxicity in MCF-7cell line by 3-(4,5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay at concentrations of 640, 320, 160, 80, 40, 20, 10 and 5 µg/mL and the half maximal inhibitory concentration (IC50) was calculated using Graph Pad Prism 5.0. As a positive control, doxorubicin was used. Phytochemical analysis of M. philippensis methanolic extract using standard tests revealed the presence of alkaloids, tannins, flavonoids, and phenolic compounds. When the cells were exposed to different concentrations of the extracts, a dose-dependent reduction in cell viability was observed. The IC50 of M. philippensis methanolic extract is 41.28 µg/mL. The antiproliferative effect of methanolic extract of M. philippensis in cancer cells in a dose dependent manner could be a promising strategy in chemotherapy. This extrapolates the use of natural products in drug designing conducting clinical trials in vivo and in human subjects.
Cancer, Mallotus philippensis, MCF-7 Cell lines, MTT Assay
HOW TO CITE THIS ARTICLE
Mariya A, Begum N, Mohan A, Sujith S, Nisha AR. Antiproliferative effect of methanolic extract of Mallotus philippensis in MCF-7 cell lines. J Phytopharmacol 2024; 13(1):1-3. doi: 10.31254/phyto.2024.13101
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