ISSN: 2320-480X
Manuscript Submission

The Journal of Phytopharmacology 2024; 13(1):1-3 ;   DOI:10.31254/phyto.2024.13101

Research Article

Antiproliferative effect of methanolic extract of Mallotus philippensis in MCF-7 cell lines

Sujith Samraj1 , Nisaath Begum2 , Alfin Mariya3 , Arya Mohan4 , Nisha AR5

1. Assistant Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Kerala 680651, India
2. Ph D scholar, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, India
3. MSc Scholar, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur 680651, India
4. Teaching Assistant, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur 680651, India
5. Associate Professor and Head, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur 680651, India

*Author to whom correspondence should be addressed.

Received: 1st October, 2023 / Accepted: 15th December, 2023 / Published : 28th February, 2024

Abstract


Phytochemicals and their derivatives are promising options for improving cancer treatment efficiency while minimising side effects. Methanolic extract of flowers of Mallotus philippensis were assessed for their cytotoxicity in MCF-7cell line by 3-(4,5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay at concentrations of 640, 320, 160, 80, 40, 20, 10 and 5 µg/mL and the half maximal inhibitory concentration (IC50) was calculated using Graph Pad Prism 5.0. As a positive control, doxorubicin was used. Phytochemical analysis of M. philippensis methanolic extract using standard tests revealed the presence of alkaloids, tannins, flavonoids, and phenolic compounds. When the cells were exposed to different concentrations of the extracts, a dose-dependent reduction in cell viability was observed. The IC50 of M. philippensis methanolic extract is 41.28 µg/mL. The antiproliferative effect of methanolic extract of M. philippensis in cancer cells in a dose dependent manner could be a promising strategy in chemotherapy. This extrapolates the use of natural products in drug designing conducting clinical trials in vivo and in human subjects.

Keywords

Cancer, Mallotus philippensis, MCF-7 Cell lines, MTT Assay


HOW TO CITE THIS ARTICLE

Mariya A, Begum N, Mohan A, Sujith S, Nisha AR. Antiproliferative effect of methanolic extract of Mallotus philippensis in MCF-7 cell lines. J Phytopharmacol 2024; 13(1):1-3. doi: 10.31254/phyto.2024.13101

Creative Commons (CC) License-

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) license. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (http://creativecommons.org/licenses/by/4.0/).

Copyright

Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.

Technical Support

×